The UCSC Genome Browser database: 2027 update.

The UCSC Genome Browser’s 2027 update adds 28 new annotation tracks—covering variant interpretation, gene regulation, and transcriptome expression—alongside QuickLift and new display customization options.

• Why it matters: The Genome Browser is widely used to visualize and compare annotations across many genome assemblies, but users need faster annotation transfer, better configuration editing, and improved track discovery and management.
• What they did: The update includes full QuickLift for copying annotations between related assemblies, HubSpace live editing for configuration files, and display options like “My Annotations” plus custom item coloring.
• The result: It also improves genome assembly discovery and track management and expands content with 28 new tracks, including ENCODE4 cCREs, variant frequencies and phased variants, and two massively parallel reporter assay tracks.

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