Nucleic Acids ResJClub
Ribocentre-FoldBridge: a comprehensive database bridging RNA chemical probing data and 3D structures.
Nucleic Acids Research · · Journal Article
Sun, Hu + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Ribocentre-FoldBridge links 256,929 RNA chemical probing profiles to 5,321 experimentally determined 3D structure–linked cases across 12 RNA types, enabling nucleotide-resolution alignment.
- Why it matters: Chemical probing is high-throughput but structural models are lower throughput, and cross-modality alignment is needed to support reproducible RNA structure–function analyses.
- What they did: The AI-assisted, curator-reviewed database connects curated probing profiles with experimentally determined 3D structures and provides interactive visualization aligned to secondary and tertiary structure at nucleotide resolution.
- The result: It shows probe-specific reactivity patterns across paired, unpaired, and solvent-accessible structural contexts, supporting reproducible evidence for developing RNA structure or function prediction programs.
The findingWhy it mattersWhat they didThe result
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