LncRNAfunc 2.0: an evidence-integrated knowledgebase for regulatory and functional interpretation of lncRNAs in cancer.

lncRNAfunc 2.0 is an updated cancer lncRNA knowledgebase that integrates multi-source evidence, expanding binding/interaction and adding perturbation evidence for regulatory interpretation.

• Why it matters: Functional annotation of cancer lncRNAs is often fragmented across heterogeneous resources and relies heavily on associations and computational predictions rather than consolidated experimental evidence.
• What they did: The team reprocessed pan-cancer TCGA data, added normal-tissue and cancer-cell-line context from GTEx and CCLE, expanded binding/interaction evidence, and introduced perturbation evidence for lncRNAs and regulators.
• The result: By combining association-based analyses with computational predictions and organizing knowledge into six functional dimensions, it links lncRNA regulatory determinants to downstream molecular relationships and tumor phenotypes, including drug response.

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