OrganiZymeDB: a comprehensive database of enzyme stability and function in the presence of organic solvents.

OrganiZymeDB compiles 28,121 manually curated measurements across 704 proteins, linking enzyme stability and function to organic solvent identity and volume fraction for industrial biocatalysis research.

• Why it matters: Limited enzyme tolerance to organic solvents hampers industrial biocatalysis, and decades of experiments lacked a public, systematic resource to enable reuse and large-scale analyses.
• What they did: The database aggregates data from 646 publications and annotates each entry with assay type, solvent details, solution composition, pH, temperature, substrates/products, production method, and protein 3D structure with cross-links.
• The result: OrganiZymeDB provides accessible solvent-compatibility data for enzyme selection and a curated dataset to develop and evaluate computational methods for predicting enzyme solvent tolerance.

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