iGPSC-DB: a comprehensive database for an inferred single-cell genetic perturbation atlas.

iGPSC-DB curates inferred links between 178 114 genetic perturbation events targeting 7407 genes and 9 249 080 tumor microenvironment single cells across 88 cancer types.

• Why it matters: Tumor phenotypes and microenvironment interactions shift after genetic perturbations, but heterogeneous cell-specific responses are hard to map and interpret for target discovery.
• What they did: The database aggregates data from 1580 samples across 88 cancer types and provides tools to retrieve inferred perturbation–cell associations and perturbation effects on functions, trajectories, and cell-cell communication.
• The result: It enables analyses of combined perturbations, malignant-cell differentiation and functional-state changes, and associations between perturbed target genes and clinical survival outcomes.

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