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Microbiome-wide PheWAS links gut microbial SNVs to health and exposures.
Nature · · Journal Article · Open access
Wang, Goumagias + more
Abstract ↗AI summary
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A microbiome-wide PheWAS in 10,781 individuals links 12.8 million gut microbial SNVs to 244 host health phenotypes and exposures, yielding 940 independent associations across 69 host factors.
- Why it matters: Species-level gut composition can miss strain-level genetic diversity, limiting how well microbial genetics can be connected to disease and environmental context in humans.
- What they did: The study tested 12.8 million microbial SNVs against 244 host phenotypes and exposures using data from 6 independent cohorts, then mapped host-phenotype-associated SNVs to functionally important protein regions.
- The result: It found 940 independent associations, including an age-associated SNV in Faecalibacterium prausnitzii affecting an amino acid in a glutathione-binding pocket, and released summary statistics in an online catalogue to enable hypothesis generation.
The findingWhy it mattersWhat they didThe result
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- Open access
- 3 cites