TASTY AND HEALTHY DIET REDUCES FECAL CALPROTECTIN IN HIGH-RISK FIRST-DEGREE RELATIVES OF PATIENTS WITH CROHN'S DISEASE: PIONIR RANDOMIZED CROSSOVER TRIAL.

Tasty&Healthy diet lowered fecal calprotectin in high-risk first-degree relatives of Crohn’s disease patients with persistently elevated baseline FC, with week-8 median 64 vs 112 µg/g.

• Why it matters: Preventing new-onset inflammatory bowel disease is a priority, but it is unclear whether low-grade intestinal inflammation in at-risk, endoscopy-negative relatives can be reduced by diet.
• What they did: In the PIONIR randomized crossover trial, 29 first-degree relatives with fecal calprotectin >70 µg/g and nonspecific mucosal findings received Tasty&Healthy or habitual diet for 8 weeks, then crossed over.
• The result: Fecal calprotectin fell by ≥50% in 71% on Tasty&Healthy versus 27% on habitual diet (RR=2.68, P=.016), with estimated marginal mean FC decreasing 61% to 72 µg/g vs 38% to 114 µg/g (ratio 0.63, P<0.001).