Development of the Children's Oncology Group long-term follow-up guideline for cancer genetics evaluation in childhood cancer survivors.

Up to 12% of childhood cancer survivors have an underlying cancer predisposition syndrome (CPS), increasing risk for subsequent malignant neoplasms and death.

• Why it matters: Identifying which survivors have CPS is essential to improve outcomes through tailored screening, treatment, and possible risk-reducing interventions.
• What they did: An evidence-based, standardized referral guideline for cancer genetics evaluation was developed for childhood cancer survivors at high risk of CPS and incorporated into the Children’s Oncology Group Long-Term Follow-Up Guidelines.
• The result: The guideline is expected to improve integration of genetics into survivorship care, supporting better health outcomes for childhood cancer survivors with CPS.