MARDy 2.0: a platform for exploring and analysing antifungal resistance mutations.

MARDy 2.0 offers an enhanced, interactive platform for analyzing antifungal resistance mutations with structural and sequence data from multiple sources.

• Why it matters: Understanding genetic and molecular mechanisms of antifungal resistance is crucial for managing clinical treatments and agricultural disease control amid rising resistance threats.
• What they did: The platform integrates data from FungAMR, UniProtKB, and AlphaFold, providing tools such as search filtering, BLAST searches, natural-language queries, mutation visualization, and structural mutation mapping.
• The result: MARDy 2.0 facilitates research into antifungal resistance evolution, surveillance, and mitigation, supporting efforts to address the growing public health and food security challenges.