Ten simple rules to build genomics capacity for routine laboratory practice in the Global South.

Implementing and sustaining genomics capacity in the Global South requires human-centered approaches, strategic planning, and equitable collaboration, as outlined by ten simple rules.

• Why it matters: Building sustainable genomics infrastructure is essential for transforming research tools into routine public health instruments in low- and middle-income countries, addressing a critical gap in health systems.
• What they did: The authors draw on lessons from regional capacity-building initiatives to propose ten rules emphasizing local context, continuous learning, and institutional collaboration for integrating genomics into routine laboratory practice.
• The result: Following these rules can help laboratories in the Global South develop sustainable genomics capacity, enabling improved diagnosis, surveillance, and decision-making in public health.