DRAMP 5.0: an update integrating sequence and structure in a novel FASTS format for AI-driven design of antimicrobial peptides.

DRAMP 5.0 introduces a novel FASTS format that integrates sequence and structural information, with 22,298 entries annotated in this format, enhancing AMP data resources.

• Why it matters: Current AMP databases mainly focus on sequence and activity data, lacking detailed annotation of non-natural amino acids and chemical modifications, which limits structure-aware analysis and AI-driven design.
• What they did: The update incorporates a new FASTS format that embeds SMILES representations into FASTA annotations, enabling simultaneous storage of sequence and structural data for over 22,000 peptides in DRAMP.
• The result: This unified format improves the accuracy of structure-aware sequence analysis and supports AI/ML-based peptide prediction and design, advancing AMP research and discovery efforts.