The H3K27me3-NR1D1-IFN-γ axis in trained macrophages induced by early respiratory virus infection drives non-T2 asthma in children.

The H3K27me3-NR1D1-IFN-γ axis in lung-trained macrophages associated with early respiratory viral infection drives non-T2 asthma in childhood mice.

• Why it matters: Understanding the mechanisms behind non-T2 asthma is crucial because its pathophysiology remains largely unexplored, unlike T2 asthma, limiting targeted treatments for affected children.
• What they did: Researchers used a non-T2 asthma mouse model with early respiratory viral infection to identify the H3K27me3-NR1D1-IFN-γ axis in lung-trained macrophages, focusing on molecular interactions and immune responses.
• The result: The study found that this axis promotes non-T2 asthma by enhancing Th1 differentiation, with potential therapeutic targets including SAM, NR1D1, and IFN-γ, as evidenced by inhibition of asthma symptoms in mice.