The role of the respiratory microbiome in acute and chronic respiratory diseases.

Diverse respiratory microbiomes undergo compositional changes in disease that predict clinical outcomes and may contribute to pathogenesis.

• Why it matters: Understanding how microbial communities influence respiratory disease progression is crucial for developing targeted diagnostics and therapies.
• What they did: The review synthesizes recent research on respiratory microbiome dynamics, including in vivo and ex vivo findings, and examines how these communities interact with immune responses and treatment outcomes.
• The result: Insights into respiratory dysbiosis may enable improved diagnosis, prognosis, and therapeutic strategies by targeting microbiome alterations in acute and chronic lung diseases.