Towards broader-spectrum direct-acting antivirals against RNA viruses.

Broader-spectrum direct-acting antivirals targeting multiple RNA virus families could address unmet medical needs and improve pandemic preparedness.

• Why it matters: Many life-threatening RNA virus infections lack effective antiviral treatments, highlighting the urgent need for broad-spectrum drugs to combat diverse viral threats and enhance epidemic response.
• What they did: The review examines approved and investigational antiviral agents active against RNA viruses, exploring biological factors that determine their antiviral range and discussing strategies for accelerated clinical development.
• The result: Advancing broad-spectrum antivirals will enable more effective management of RNA virus infections across multiple genera and families, strengthening global health defenses against outbreaks.