Turning the tables: Repurposing neuroplasticity to defeat cancer.

Cancer reprograms peripheral nerves to promote immune evasion, and targeting this process can restore responses to immunotherapy.

• Why it matters: Understanding how cancer interacts with nerves is crucial because nerve involvement may hinder effective immune responses and limit immunotherapy success.
• What they did: The work investigates how cancer injures and reprograms peripheral nerves, using experimental approaches to identify mechanisms of nerve-driven immune evasion.
• The result: Targeting nerve reprogramming may reverse immune evasion, suggesting a new strategy to enhance immunotherapy effectiveness against cancer.