Progressive remodeling of global protein interaction networks in a mouse model of tauopathy.

Protein interaction networks in a mouse tauopathy model undergo significant, phosphorylation-dependent remodeling, with over 20 key complexes showing dynamic changes during disease progression.

• Why it matters: Understanding how protein interactions change over time in neurodegenerative diseases can reveal early pathogenic mechanisms and potential therapeutic targets, yet this dynamic rewiring remains poorly characterized.
• What they did: The study used co-fractionation mass spectrometry, quantitative phosphoproteomics, and machine learning to create a comprehensive, temporally resolved map of protein complex remodeling in a tauopathy mouse model.
• The result: This interactomic atlas uncovers how phosphorylation influences complex architecture and function, providing a framework to dissect molecular mechanisms driving neurodegeneration and identify early intervention points.