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Phosphoglycerate kinase 1 cooperates with the AP2 complex to promote endocytosis.
EMBO Reports · · Journal Article · Open access
Chu, Chang + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Phosphoglycerate kinase 1 (PGK1) acts as a co-adaptor with the AP2 complex, enhancing cargo recognition and promoting endocytosis independently of its enzymatic activity.
- Why it matters: Understanding how adaptor proteins coordinate cargo recognition is crucial for elucidating intracellular transport mechanisms, which are vital for cell function and signaling.
- What they did: The study used biochemical and cellular approaches to demonstrate that PGK1 directly interacts with cargoes and stabilizes the AP2 complex, forming a novel coat protein complex involved in endocytosis.
- The result: This discovery reveals PGK1’s dual role as a cargo adaptor and AP2 stabilizer, providing new insights into the regulation of endocytosis and potential targets for modulating cellular uptake processes.
The findingWhy it mattersWhat they didThe result
- Open access