Integrated multi-omics analysis identifies PPAR signaling network associations with metabolic-immune dysregulation and intestinal injury in PDCoV-infected piglets.

Integrated multi-omics analysis reveals PPAR signaling network activation linked to lipid metabolism disruption and intestinal injury in PDCoV-infected piglets, with a key role for PPAR pathway genes.

• Why it matters: Understanding host response networks in PDCoV infection is crucial because the disease causes severe diarrhea and high mortality in piglets and can infect human cells, highlighting potential cross-species risks and therapeutic targets.
• What they did: Researchers conducted combined transcriptomic, proteomic, and metabolomic profiling of jejunal tissues from PDCoV-infected piglets, identifying key alterations in PPAR signaling and lipid metabolism pathways.
• The result: Findings suggest PPAR pathway modulation contributes to lipid resource reallocation and inflammation, offering potential targets for therapy and indicating shared pathogenic mechanisms with SARS-CoV-2.