The evolving landscape of drug targets.
The drug target landscape has expanded to include 686 biomolecules modulated by 1,702 drugs over the past 25 years, reflecting significant advances in discovery methods.
- Why it matters: Understanding how the drug target landscape has evolved is crucial for developing new therapies, especially for diseases previously lacking effective treatments, addressing unmet medical needs.
- What they did: The authors mapped and quantified changes in the number and types of drug targets, analyzing trends driven by advances in genetics, genomics, proteomics, and therapeutic modalities.
- The result: This comprehensive analysis highlights ongoing and future shifts in target druggability, supporting the development of innovative treatments and expanding therapeutic options.