Programmable plant chassis for sustainable biomanufacturing of high-value natural products.

Synthetic biology advances have enabled plants to serve as programmable chassis for producing high-value natural products, with recent pathway engineering achieving significant productivity gains.

• Why it matters: Plant-based biomanufacturing offers sustainable, CO2-fixing platforms for complex molecule synthesis, addressing the need for environmentally friendly alternatives to traditional chemical production.
• What they did: The review summarizes recent developments in genetic elements and pathway engineering strategies for alkaloids, terpenoids, and phenylpropanoids, highlighting methods to improve yields and scalability.
• The result: These innovations pave the way for large-scale industrial applications of plant chassis, facilitating sustainable biomanufacturing and expanding the potential of plant-based production systems.