KDM6A loss enhances oxidative phosphorylation uncovering tissue-level convergent evolution.

Loss of KDM6A enhances oxidative phosphorylation across multiple tissues, revealing a conserved mechanism of tissue-level convergent evolution in cancer and development.

• Why it matters: Understanding how KDM6A loss drives metabolic reprogramming is crucial because it uncovers common pathways in diverse cancers and tissues, offering potential therapeutic targets and insights into tissue-specific adaptations.
• What they did: The study analyzed KDM6A-deficient tumors and tissues, demonstrating that its loss activates oxidative phosphorylation through two distinct pathways involving CCDC3-CREB1 or TRAF3IP3-mTORC1, depending on the context.
• The result: This work highlights KDM6A as a key regulator of mitochondrial activity, enabling tissue-specific metabolic adaptations and suggesting convergent evolution of mitochondrial regulation mechanisms across different biological systems.