Androgen-PDH axis modulates sexual dimorphism of mitochondrial respiration in visceral fat.

Androgen-AR signaling suppresses mitochondrial respiration in visceral fat by downregulating Pdhb, contributing to sex differences in fat accumulation and metabolic risk.

• Why it matters: Understanding the mechanisms behind sex-specific differences in adipose mitochondrial function is crucial for addressing metabolic diseases linked to visceral fat.
• What they did: The study used multi-omics analyses, gene overexpression, and pharmacological activation of PDH in mice to investigate how androgen-AR signaling influences mitochondrial activity in visceral adipose tissue.
• The result: Findings show that activating Pdhb or PDH enhances mitochondrial function and reduces visceral fat in males, revealing the androgen-PDH axis as a potential target for metabolic disorder interventions.