Towards precision psychiatry: initial foundations and future directions.

Precision psychiatry leverages biomarkers to improve treatment targeting, with initial success in stratified trials for postpartum depression and schizophrenia.

• Why it matters: Current symptom-based diagnoses hinder effective treatment development, creating a critical need for biologically grounded approaches to understand and treat psychiatric disorders.
• What they did: The approach involves using patient-specific measures like EEG, fMRI, and peripheral biomarkers to elucidate neural dysfunctions, predict treatment responses, and guide targeted interventions across 4 key mechanistic frameworks.
• The result: This strategy enables more precise clinical trials and biology-driven therapies, potentially reducing development risks and enhancing outcomes in psychiatric drug discovery.