Neutrophil-integrated syncytial CAR macrophage for cancer immunotherapy.

Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and reduce tumor burden in mouse models of cancer.

• Why it matters: Overcoming the limited effectiveness of CAR-M therapy is crucial for treating solid tumors, especially those with low target antigen expression and immune evasion.
• What they did: Researchers fused CAR macrophages with neutrophils to create S-CAR-Ms, which showed increased tumor accumulation via chemokine-driven migration and enhanced tumor cell phagocytosis through multiple pathways.
• The result: A single dose of S-CAR-Ms reduced metastasis, prevented tumor recurrence, and triggered antigen spreading, suggesting improved potential for solid tumor immunotherapy.