P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice.

P-selectin marks early functional heterogeneity in aging hematopoietic stem cells, with high expression linked to increased DNA damage and myeloid bias in humans and mice.

• Why it matters: Understanding early molecular changes in HSC aging is crucial for developing strategies to prevent age-related blood disorders and restore healthy hematopoiesis.
• What they did: The study analyzed 2,000+ HSCs from humans and mice, identifying P-selectin (Selp) as a surface marker that distinguishes functional states and transcriptional programs during aging.
• The result: Findings show Selp high HSCs exhibit pro-inflammatory and oxidative stress signatures, while Selp low HSCs maintain metabolic health, positioning P-selectin as a target for rejuvenation therapies.