The genetic architecture of fibromyalgia across 2.5 million individuals.

Genetic analysis of 2.5 million individuals reveals fibromyalgia as a central nervous system disorder with 26 risk loci, including a key variant in HTT.

• Why it matters: Understanding the genetic basis of fibromyalgia addresses the gap in knowledge about its complex etiology and helps clarify its biological mechanisms, which are currently poorly understood.
• What they did: A multi-ancestry genome-wide association study meta-analysis was performed on over 2.5 million people, identifying risk loci and neural gene associations, with heritability enriched in brain tissues.
• The result: Findings establish fibromyalgia’s strong genetic links to neural pathways and comorbidities, providing a biological framework that can inform future research and targeted therapies.