Cancer CellJClub
GABA promotes resistance to immunotherapy in patients with TLS-positive tumors.
Cancer Cell · · Journal Article
Hernández-Verdin, Calvez + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
GABA upregulation in TLS-positive tumors is linked to resistance to immune checkpoint inhibitors in ccRCC and STS patients.
- Why it matters: Understanding why some TLS-positive tumors do not respond to ICIs is crucial for improving immunotherapy outcomes, as TLS presence alone does not guarantee treatment success.
- What they did: Multi-omic profiling of ccRCC and STS tumors identified increased GABA-related signatures in non-responders; in vitro and mouse models tested GABA's immunoregulatory effects and GABA-synthesis inhibition.
- The result: Inhibiting GABA synthesis enhanced ICI response and immune cell infiltration, especially B cells, suggesting GABA as a target to overcome resistance in TLS-positive tumors.
The findingWhy it mattersWhat they didThe result
- 2 cited this week