The future of marsupial gene editing: What's in the (tool) pouch?

Marsupial genome editing has been achieved only in Monodelphis domestica, limiting broader research and conservation applications across diverse species.

• Why it matters: Expanding genome editing in marsupials is crucial for advancing their use as models in clinical and evolutionary studies and for addressing ecological challenges they face.
• What they did: The review discusses marsupial-specific challenges and opportunities in zygote-based and germ cell transplantation methods, highlighting ongoing efforts to develop genome editing tools for multiple species.
• The result: Progress in this area will enhance the utility of marsupials in research and conservation, enabling targeted genetic interventions and improved understanding of their unique biology.