Sustainable mevalonate bioproduction: A comprehensive review of microbial biosynthesis and downstream processing technologies.

Microbial biosynthesis of mevalonate can significantly enhance sustainability and cost-effectiveness compared to conventional chemical synthesis methods.

• Why it matters: Mevalonate is a key precursor for industrially important compounds, but traditional chemical synthesis faces major limitations, creating a need for more sustainable production approaches.
• What they did: The review analyzes recent advances in MVA biosynthesis, including production by native and engineered hosts, and explores strategies like metabolic engineering, mixed-culture systems, and cell-free platforms, along with downstream extraction techniques.
• The result: Findings highlight progress in improving biosynthesis efficiency and extraction methods, guiding future efforts toward overcoming current challenges and advancing sustainable MVA bioproduction.