Identification and characterization of new P. aeruginosa phages using a surface receptor platform

Two new Pseudomonas aeruginosa phages, Dalewood and Bowman, were isolated and characterized using the SURFAR receptor platform, targeting flagella/LPS and biofilms, respectively.

• Why it matters: Receptor-based phage steering and cocktail design require knowing which bacterial receptors phages use, and finding phages that exploit diverse receptors to limit resistance.
• What they did: The SURFAR platform uses defined Pseudomonas aeruginosa strains and mutants to rapidly characterize phage receptors and to enrich diverse phages from wastewater.
• The result: Dalewood targets both flagella and the conserved LPS outer core, while Bowman is a biofilm-targeting phage that suppresses growth of a subset of carbapenem-resistant clinical isolates.

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