The Pseudomonas protegens PBL3 secretome exerts antimicrobial activity against Burkholderia glumae by disrupting cell envelope homeostasis and impairing bacterial replication

The Pseudomonas protegens PBL3 secretome causes extensive cell envelope damage in Burkholderia glumae, leading to cell death and impaired bacterial multiplication.

• Why it matters: Antimicrobial resistance threatens single-target drugs, so multi-target agents that disrupt several cellular processes are needed to reduce resistance development.
• What they did: Using Burkholderia glumae as a plant pathogen model, the study tested the PBL3 secretome’s effects and used transcriptomic analysis to assess envelope biogenesis, homeostasis, and replication pathways.
• The result: The secretome is linked to broad disruption of cell-envelope biogenesis and homeostasis and bacterial replication, supporting its potential as a multi-target antimicrobial for agricultural and medical bacterial infections.

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