Early Increases in Hippocampal Synchrony Predict Chronic Epileptiform Burden in a Temporal Lobe Epilepsy Model

Early increases in hippocampal CA1 synchrony within three weeks after pilocarpine induction predict chronic epileptiform burden in a 16-week temporal lobe epilepsy mouse model.

• Why it matters: Seizure counts miss epileptiform activity that may better track progression, but it is unknown whether hippocampal network reorganization reflects and predicts chronic severity.
• What they did: The study used longitudinal two-photon calcium imaging in CA1 alongside repeated 24-hour EEG over 16 weeks in the same pilocarpine-treated mice, tracking synchrony and epileptiform burden over time.
• The result: CA1 synchrony correlated with epileptiform burden and stratified mice into distinct neuronal and electrographic outcomes, enabling early synchrony to serve as a candidate imaging biomarker and intervention window.

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