Insulin genetic clusters and clinical outcomes in Hispanics/Latinos

In 12,631 Hispanic/Latino participants in HCHS/SOL, the Lipodystrophy fasting insulin cluster-specific polygenic score is linked to type 2 diabetes (p=3.5 x 10-5).

• Why it matters: Fasting insulin reflects insulin resistance, but cluster-specific genetic mechanisms have not been evaluated for liver outcomes in this population.
• What they did: The study computed seven previously developed FI cluster-specific polygenic scores from 19 metabolic traits and tested associations with type 2 diabetes, cardiovascular, kidney, and liver outcomes in HCHS/SOL.
• The result: Adiposity-driven Hyperinsulinemia scores were linked to hepatic steatosis index (p=2.2 x1017) and fatty liver index (p=1.7 x1014), while Liver/Lipid scores were linked to liver fibrosis (p=1.5 x104) and lower kidney function (p=5.2 x 10-5).

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