Door-to-Valve Time and Clinical Outcomes in Acute Decompensated Severe Aortic Stenosis: Systematic Review and Meta-Analysis

In acute decompensated aortic stenosis, delayed door-to-valve intervention is not significantly linked to long-term all-cause mortality (HR 1.52, 95% CI 0.46–5.00).

• Why it matters: Acute decompensation has high mortality, yet the optimal timing of TAVR or BAV after admission is unclear, and observational evidence may be biased.
• What they did: A systematic review and meta-analysis searched Embase, Ovid MEDLINE, and CENTRAL to May 15, 2026, pooling hazard ratios for delayed versus earlier intervention from eight observational cohorts (n=6,044).
• The result: Short-term crude mortality was higher with delayed intervention (RR 4.96, 95% CI 1.17–20.92), but sensitivity analyses were not robust, and serious risk of bias with heterogeneity limits conclusions.

AI summary of the abstract · may contain errors · not medical advice · read the paper.