Baseline Severity and Early Multiorgan Failure to Predict In-Hospital Mortality in Critically Ill COVID-19 Patients: A Retrospective Cohort Study

Early multiorgan failure at 24 hours in 345 adults with severe COVID-19 pneumonia in a Spanish ICU is linked to higher in-hospital mortality, with AUC rising to 0.812.

• Why it matters: Admission severity scores may not reflect the evolving trajectory of critically ill patients, leaving clinicians with limited discrimination for mortality risk.
• What they did: In a retrospective single-center cohort (March 2020–December 2022), investigators compared models using AUC-ROC and estimated mortality odds with multivariable logistic regression.
• The result: In-hospital mortality was 20.6%, and early MOF was more common in non-survivors (88.4% vs. 61.7%); it nearly tripled death odds (OR 2.78, 95% CI 1.22–6.33, p=0.015).

AI summary of the abstract · may contain errors · not medical advice · read the paper.