Rapid early degradation of Cyclin A is important to maintain genomic stability

Slowing APC/C-mediated degradation of human CyclinA2 causes altered microtubule dynamics, chromosome congression errors, and aneuploidy with malformed daughter nuclei at mitotic exit.

• Why it matters: Rapid early CyclinA destruction is conserved, but its physiological role in maintaining genomic stability was unclear.
• What they did: Human CyclinA2 was engineered by mutating two APC/C-recognition motifs to slow degradation, and mitotic outcomes were assessed, including microtubule dynamics and chromosome congression.
• The result: Slower CyclinA degradation induces chromosome clustering defects at mitotic exit, linked to perturbed Ki67 phosphorylation and behaviour, implying rapid CyclinA degradation supports genomic stability.