medRxiv · 6 Aug 2026 · Preprint · Open access

Exploring Potential Minocycline-ARH3 Interactions in ADPRHL2-Associated CONDSIAS: A Translational Clinical and Computational Study

Barazandeh Shirvan, Nejabat + 22 more

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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment activates p300, causing a 50% reduction in PARPi effectiveness in epithelial ovarian cancer.
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Mechanisms and disease relevance of DNA break repair pathway choice.
Nature Reviews Molecular Cell Biology · 18 Sept 2026 · Review
DNA double-strand break repair pathway choice is governed by complex mechanisms involving chromatin modifications and key repair factors, with BRCA1-BARD1 and 53BP1 playing antagonistic roles.
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Yeast Rad55-Rad57-SHU paralog complex dynamically promotes Rad51 filament formation.
Molecular Cell · 17 Sept 2026 · Journal Article
Yeast Rad55-Rad57-SHU complex enhances Rad51 filament formation through dynamic structural and nucleotide-regulated mechanisms.
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