bioRxiv · 1 Sept 2026 · Preprint · Open access

Targeted mutagenesis of specific genomic DNA sequences in animals for the in vivo generation of variant libraries

Falo-Sanjuan, Diaz-Tirado + 15 more

Open access
2 cites

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RNA-Triggered Chromatin Shredding Hits Cancer's Hardest Targets.
Cancer Discovery · 23 June 2026 · News
RNA-triggered chromatin shredding using Cas12a2 selectively eliminates tumor cells with mutations in critical cancer genes like TP53 and MYC in mouse models.
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Optimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish.
eLife · 7 July 2026 · Journal Article
Prime editors achieve up to 27.3% precise DNA insertions in zebrafish, enabling accurate genome modifications without exogenous DNA.
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- 3 cites
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https://jclub.com.au/a/42411453
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