TTPdb: a comprehensive database of targeted therapeutic peptides.

TTPdb consolidates 5366 targeted therapeutic peptides—106 approved, 229 clinical, and 5031 preclinical/investigative—spanning >600 disease types with 3D structures, binding interactions, and physicochemical properties.

• Why it matters: Data on targeted therapeutic peptides are fragmented across sources, and there is no dedicated platform to integrate them for mechanistic exploration or rational peptide engineering.
• What they did: The database compiles peptide information including 3D structures, binding interactions, structural modifications, pharmacological mechanisms, and links among peptides, targets, and diseases, plus multidimensional search with keyword, conditional filters, and FASTA homology.
• The result: TTPdb enables systematic querying and association-driven analysis to support rational peptide design and optimization for AI-driven biomedical research, and it is freely accessible at https://idrblab.org/TTPdb.