MAKR6 integrates TMK and CAMEL/CANAR signalling for auxin canalization in Arabidopsis.

MAKR6 is essential for auxin canalization in Arabidopsis by regulating PIN1 trafficking and integrating TMK1/4 and CAMEL-CANAR signalling pathways.

• Why it matters: Understanding auxin canalization is crucial for revealing how plants form vascular tissues and regenerate vasculature, yet the regulatory mechanisms remain unclear.
• What they did: Researchers identified MAKR6 as a component of auxin feedback, showing its accumulation in vascular cells, regulation by auxin via the Aux/IAA-ARF-WRKY23 cascade, and interaction with PIN1 and receptor-like kinases TMK1/4 and CAMEL-CANAR.
• The result: MAKR6 couples auxin signalling to PIN1 polarization and coordinates RLK pathways, providing mechanistic insight into auxin canalization and a framework for exploring similar regulatory nodes in plant development.