High-risk antimicrobial resistance genomic traits in multidrug-resistant Salmonella across China's food chain: projections to 2050.

Eighty-four high-risk antimicrobial resistance traits in MDR Salmonella are projected to increase by 2050, driven by socioeconomic, climate, and healthcare factors in China.

• Why it matters: Understanding the factors influencing AMR genomic evolution is crucial for developing effective interventions, especially as resistance traits threaten public health globally.
• What they did: Researchers analyzed 2,536 MDR Salmonella genomes from 15 Chinese provinces over 16 years, using machine learning and regression models to map trait prevalence and forecast future trends up to 2050.
• The result: Projections indicate specific resistance genes, such as bla CTX-M-64 and bla TEM-1, may increase up to 20%, with food workers identified as potential reservoirs carrying last-resort resistance genes, highlighting the importance of integrated genomic and socioeconomic surveillance.