H3K4me1-Mediated Epigenomic Priming of Chemoresistant Tumor States in Ovarian Cancer.

Epigenetically primed tumor cell states marked by H3K4me1 predict chemoresistance in high-grade serous ovarian cancer.

• Why it matters: Understanding how resistant tumor states are encoded in patients can improve prediction and treatment strategies for therapy failure in cancer.
• What they did: The study used multimodal single-nucleus approaches to profile transcriptional programs and histone modifications from longitudinal biopsies of 16 HGSOC patients, revealing that resistant programs are broadly enriched for H3K4me1 prior to treatment.
• The result: Baseline tumor composition linked to survival, with resistant states epigenetically primed by H3K4me1, providing a scalable framework to anticipate resistance from biopsies.