EvoNiche: a comprehensive database for dissecting tumor niche dynamics and spatiotemporal evolution within the cancer ecosystem.

EvoNiche reveals 5609 spatial niches and reconstructs tissue- and cell-level spatiotemporal trajectories across 35 cancer types.

• Why it matters: Understanding tumor development, metastasis, and therapy response requires detailed knowledge of how tumor niches evolve and organize spatially over time.
• What they did: EvoNiche integrates 91 spatial and single-cell transcriptomic datasets, encompassing nearly 2 million spatial spots and 3 million cells, to analyze tumor ecosystem dynamics.
• The result: This resource enables comprehensive characterization of tumor remodeling, identifies region-specific genes, and offers insights into mechanisms driving tumor progression and treatment outcomes.