Interventions to mitigate post-infection morbidity: Management insights from simple models.

Long-term use of nonpharmaceutical interventions and post-infection effects influence optimal vaccination coverage and societal costs, with some models showing a transmission-independent vaccination level.

• Why it matters: Understanding how post-infection morbidity impacts long-term disease management is crucial for designing effective policies that minimize societal costs and improve health outcomes.
• What they did: Mathematical models were used to analyze post-infection costs, vaccination coverage, and intervention strategies, including generalizing classic epidemiological-economic frameworks and considering vaccination cost functions.
• The result: Post-infection effects can significantly shift incentives toward disease elimination, and small changes in vaccination costs or post-infection costs can dramatically alter optimal coverage levels, emphasizing the need for precise cost quantification.