A Gata4-Loxl2 axis controls ECM remodeling to enable scar-free spinal cord regeneration in zebrafish.

Gata4-Loxl2b axis is essential for ECM remodeling and scar-free spinal cord regeneration in zebrafish, with loss of Gata4 impairing recovery.

• Why it matters: Understanding how zebrafish avoid fibrosis during spinal cord regeneration could inform therapies for mammals, where scar formation blocks axon regrowth and functional recovery.
• What they did: The study used injury models to show Gata4 is induced in ERGs, suppresses ECM gene expression, and regulates Loxl2b; pharmacological inhibition of Loxl2b rescues ECM organization and recovery.
• The result: Disruption of Gata4 increases Loxl2b, causes excessive collagen cross-linking and matrix stiffening, delaying tissue bridging and impairing motor function, while Loxl2b inhibition restores regeneration.