Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila.

Loss of Lsp2 reduces TOP mRNA translation via 4E-BP, extending Drosophila lifespan independently of rapamycin, highlighting a new longevity pathway.

• Why it matters: Understanding how mTORC1 controls TOP mRNA translation and influences aging is crucial, as these processes are linked to metabolic health and lifespan regulation, yet remain incompletely understood.
• What they did: The study examined Lsp2, a storage protein and adipose effector, by genetically ablating it and analyzing its impact on mTORC1 activity, TOP mRNA translation, and lifespan in Drosophila, using translatomic profiling.
• The result: Lsp2 ablation significantly extends lifespan without affecting reproduction, by specifically reducing TOP mRNA translation through a 4E-BP-dependent mechanism, unveiling a novel nutrient-responsive longevity pathway.