TRIM62 facilitates influenza A virus entry by regulating WASH-dependent endosomal trafficking.
- Open access
TRIM62 enhances influenza A virus entry by modulating WASH-dependent endosomal trafficking, promoting viral internalization through retromer regulation.
- Why it matters: Understanding how endocytosis is balanced between cargo uptake and cellular protection is crucial for developing antiviral strategies and comprehending cellular trafficking mechanisms.
- What they did: The study examined the WASH complex's role in viral endocytosis, focusing on its subunits and their interactions with retromer components, using influenza A virus as a model.
- The result: TRIM62 maintains WASH in an active state that supports viral entry, revealing a new target for disrupting influenza infection and highlighting broader roles in lipid raft-mediated endocytosis.