Scalable near-real-time Bayesian phylogenetics for outbreaks with Delphy.

Delphy achieves 100,000-sequence Bayesian phylogenetic analysis within a day, offering 100 to 1000-fold speed improvements over traditional methods for outbreak datasets.

• Why it matters: Rapid, accurate pathogen tracking is crucial for outbreak containment, but existing tools are often too slow or costly, limiting global access and timely responses.
• What they did: Delphy employs an explicit mutation-annotated tree structure, leveraging high sequence similarity in epidemic datasets, and is implemented as a user-friendly web application for local, interactive analysis.
• The result: This approach maintains state-of-the-art accuracy while enabling fast, scalable, and accessible Bayesian phylogenetics, supporting real-time outbreak response and viral lineage tracking.