Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis.

NINJ2 maintains lysosomal membrane integrity to prevent ferroptosis, with loss increasing susceptibility by 2.5-fold in cell models.

• Why it matters: Understanding how lysosomal stability influences ferroptosis is crucial for developing targeted therapies for iron-related diseases and cancers, where cell death regulation is disrupted.
• What they did: Researchers used cellular and molecular techniques to show NINJ2 localizes to lysosomes, interacts with LAMP1, and its absence leads to increased lysosomal permeabilization and iron leakage, promoting ferroptosis.
• The result: Loss of NINJ2 enhances ferroptosis sensitivity, revealing its potential as a therapeutic target in iron-dependent cancers and inflammatory conditions by stabilizing lysosomal membranes.