Cross-cancer transcriptomic analysis reveals conserved developmental, ferroptosis, and immune remodeling modules in Wilms tumor and oral cancer.

Conserved ferroptosis and immune modules are linked to developmental dysregulation in Wilms tumor, with partial conservation across oral cancer, highlighting potential therapeutic targets.

• Why it matters: Understanding the transcriptomic relationship between developmental pathways, ferroptosis, and immune remodeling in Wilms tumor is crucial for identifying novel treatment strategies, yet this connection remains poorly characterized.
• What they did: Analyzing microarray and single-cell data from Wilms tumor and oral cancer, the study assessed six biological modules, revealing strong correlations between developmental, ferroptosis, and immune gene networks, validated by qRT-PCR in cell lines.
• The result: Findings demonstrate that ferroptosis and immune stress-response modules are partially conserved across cancers and are associated with developmental dysregulation, providing candidate modules for future functional validation and therapy development.